Luigina Romani

Luigina Romani è Professore Ordinario di Patologia al Dipartimento di Medicina Sperimentale dell’Università degli Studi di Perugia. È laureata in Scienze Biologiche e in Medicina presso lo stesso ateneo. La sua prolifica attività di ricerca vanta ottimi risultati nell’analizzare il ruolo del microbiota nel condizionare la predisposizione a infezioni. È coautrice di oltre 500 pubblicazioni su riviste internazionali. A maggio 2015 è stata insignita del prestigioso premio “Lucille Georg”, riconoscimento che viene conferito a illustri micologi che si sono distinti per i loro considerevoli apporti scientifici: il premio a Luigina Romani è stato motivato per il significativo contributo dato alla Scienza nel campo della Micologia Medica.

• Romani L, et al. Immunity to fungal infections. Nat Rev Immunol, Apr;11(4):275-88. doi: 10.1038/nri2939. Epub 2011 Mar 11
• Cunha C, Aversa F, Bistoni G et al. Immunogenetic profiling to predict risk of invasive fungal diseases: where are we now? Immunol Invest. 2011;40(7-8):723-34. doi: 10.3109/08820139.2011.586395. 
• Cunha C, Giovannini G, Pierini A et al. Genetically-determined hyperfunction of the S100B/RAGE axis is a risk factor for aspergillosis in stem cell transplant recipients. PLoS One. 2011;6(11):e27962. doi: 10.1371/journal.pone.0027962. Epub 2011 Nov 17.
• Carvalho A, Cunha C, Bistoni F, Romani L. Immunotherapy of aspergillosis. Clin Microbiol Infect. 2012 Feb;18(2):120-5. doi: 10.1111/j.1469-0691.2011.03681.x. Epub 2011 Oct 24.
• Zelante T, Iannitti R, De Luca A, Romani L. IL-22 in antifungal immunity. Eur J Immunol. 2011 Feb;41(2):270-5. doi: 10.1002/eji.201041246. Epub 2011 Jan 11.
• Sorci G, Giovannini G, Riuzzi F et al. The danger signal S100B integrates pathogen- and danger-sensing pathways to restrain inflammation. PLoS Pathog. 2011 Mar;7(3):e1001315. doi: 10.1371/journal.ppat.1001315. Epub 2011 Mar 10.
• Cunha C, Carvalho A, Esposito A et al. DAMP signaling in fungal infections and diseases. Front Immunol. 2012 Sep 10;3:286. doi: 10.3389/fimmu.2012.00286. eCollection 2012.
• Cunha C, Carvalho A. Host genetics and invasive fungal diseases: towards improved diagnosis and therapy? Expert Rev Anti Infect Ther. 2012 Mar;10(3):257-9. doi: 10.1586/eri.12.3.
• Carvalho A, Cunha C, Iannitti RG et al. Host defense pathways against fungi: the basis for vaccines and immunotherapy. Front Microbiol. 2012 May 10;3:176. doi: 10.3389/fmicb.2012.00176. eCollection 2012.
• Zelante T, Iannitti RG, De Luca A et al. Sensing of mammalian IL-17A regulates fungal adaptation and virulence. Nat Commun. 2012 Feb 21;3:683. doi: 10.1038/ncomms1685.
• Iannitti RG, Carvalho A, Cunha C et al. Th17/Treg imbalance in murine cystic fibrosis is linked to indoleamine 2,3-dioxygenase deficiency but corrected by kynurenines. Am J Respir Crit Care Med. 2013 Mar 15;187(6):609-20. doi: 10.1164/rccm.201207-1346OC. Epub 2013 Jan 10.
• Iannitti RG, Casagrande A, De Luca A, et al. Hypoxia promotes danger-mediated inflammation via receptor for advanced glycation end products in cystic fibrosis. Am J Respir Crit Care Med, 2013 Dec 1;188(11):1338-50. doi: 10.1164/rccm.201305-0986OC.
• Borghi M, Renga G, Puccetti M,et al. Antifungal Th Immunity: Growing up in Family. Front Immunol, 2014 Oct 15;5:506. doi: 10.3389/fimmu.2014.00506. eCollection 2014.
• Zelante T, Iannitti RG, Fallarino F, et al. Tryptophan Feeding of the IDO1-AhR Axis in Host-Microbial Symbiosis. Front Immunol. 2014 Dec 15;5:640. doi: 10.3389/fimmu.2014.00640. eCollection 2014.
• Bedke T, Iannitti RG, De Luca A et al. Distinct and complementary roles for Aspergillus fumigatus-specific Tr1 and Foxp3+ regulatory T cells in humans and mice. Immunol Cell Biol. 2014 Sep;92(8):659-70. doi: 10.1038/icb.2014.34. Epub 2014 May 13.
• Moretti S, Bozza S, Oikonomou V et al. L-37 inhibits inflammasome activation and disease severity in murine aspergillosis. PLoS Pathog. 2014 Nov; 10(11): e1004462
• Iannitti RG, Napolioni V, Oikonomou V et al. IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis. Nat Commun. 2016 Mar 14;7:10791. doi: 10.1038/ncomms10791. 
• Costantini C, Renga G, Oikonomou V, et al. The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface. Mediators Inflamm. 2018 Oct 28;2018:7396136. doi: 10.1155/2018/7396136. eCollection 2018.
• Puccetti M, Paolicelli G, Oikonomou V, et al. Towards Targeting the Aryl Hydrocarbon Receptor in Cystic Fibrosis. Mediators Inflamm. 2018 Feb 18;2018:1601486. doi: 10.1155/2018/1601486. eCollection 2018.
• Piliponsky AM, Romani L. The contribution of mast cells to bacterial and fungal infection immunity. Immunol Rev. 2018 Mar;282(1):188-197. doi: 10.1111/imr.12623.
• Valerio Napolioni, Marilena Pariano, Monica Borghi et al. Genetic Polymorphisms Affecting IDO1 or IDO2 Activity Differently Associate With Aspergillosis in Humans. Front Immunol. 2019; 10: 890. 
• Marilena Pariano, Matteo Puccetti, Vasilis Oikonomou, Monica Borghi, Valeria R. Villella, Claudia Stincardini, Luigi Sforna, Giorgia Renga and Luigina Romani. Anakinra in cystic fibrosis: From targeting pathogenic inflammation to correcting CFTR defects. The Proceedings of the 16th Italian Convention of Investigators in Cystic Fibrosis. Multidisciplinary Respiratory Medicine, 2019, 14 (Suppl 1):5

2005: Premio “Lucille Georg”
2003: Professore onorario presso Old Herborn University
2011: Vincitore del “Jon van Rood Award” per la migliore ricerca nel campo Transplantation Immunology/Immunogenetics, pubblicata nel 2010
2012: Vincitore del Abraham White Scientific, Humanitarian, and Public Service Award, Washington DC, USA