Enrico Millo

Enrico Millo ottiene nel 1993 la laurea in Chimica e Teconologie Farmaceutiche e nel 1994 la Laurea in Farmacia; nel 2002 consegue il titolo di Dottore di Ricerca in Biologie Cellulari e Molecolari Applicate al settore Biomedico. Dal 2009 afferisce al Centro di Eccellenza per la Ricerca Biomedica (CEBR) dell’Università degli Studi di Genova e a decorrere dal primo novembre 2017 ricopre il ruolo di professore associato per il settore scientifico – disciplinare bio/10 biochimica, presso il Dipartimento di Medicina sperimentale (DIMES) sezione biochimica dell’Università degli Studi di Genova.
Le principali tematiche di ricerca riguardano: disegno, sintesi e caratterizzazione di acidi nucleici peptidici (PNA) per strategie antisenso e anigeniche; sintesi di molecole a struttura peptidica convenzionale, retroinversa e peptido-mimetica; sintesi di oligonucleotidi modificati ad azione antivirale; sintesi e caratterizzazione di analoghi strutturali dell’acido abscissico come potenziali farmaci antiinfiammatori; progettazione e sintesi di molecole a struttura tiazolica per lo studio della fibrosi cistica.

• Ferrera L., Caputo A, Ubby I et al., Regulation of TMEM16A chloride channel properties by alternative Splicing. Journal of Biological Chemistry, 2009, 284(48):33360-8
• Sondo E., Tomati V., Caci E. et al., Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling. American Journal of Physiology-Cell Physiology, 2011, 301(4):C872-85
• Ferrera L., Scudieri P., Sondo E. et al., A minimal isoform of the TMEM16A protein associated with chloride channel activity. BBA- Biomembranes, 2011, 1808(9):2214-23
• Budriesi R., Ioan P, Leoni A. et al., Cystic fibrosis: a new target for 4-Imidazo[2,1-b]thiazole-1, 4-dihydropyridines. Journal of medicinal chemistry, 2011, 54(11):3885-94
• Giampieri M., Vanthuyne N., Nieddu E. et al., Asymmetric 4-Aryl-1,4-dihydropyridines potentiate mutant cystic fibrosis transmembrane conductance regulator. ChemMedChem, 2012, 7(10):1799-807
• Scudieri P., Sondo E., Ferrera L. et al., The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. Experimental Physiology, 2012, 97(2):177-83
• Scudieri P., Caci E., Bruno S. et al., Association of TMEM16A Chloride Channel overexpression with airway goblet cell metaplasia. Journal of Physiology, 2012, 590(23):6141-55
• Sondo E., Scudieri P., Tomati V. et al., Non-canonical translation start sites in the TMEM16A chloride channel, BBA, 2013, 1838(1 Pt B):89-97
• Scudieri P., Sondo E., Caci E. et al., TMEM16A-TMEM16B chimaeras to investigate the structure-function relationship of calcium-activated chloride channels. Journal of Biological Chemistry, 2013, 452(3):443-55
• Altamura N., Castaldo R., Finotti A. et al., Tobramycin is a suppressor of premature termination codons. Journal of Cystic Fibrosis, 2013, 12(6):806-11
• Sondo E., Caci E., Galietta LJ. The TMEM16A chloride channel as an alternative therapeutic target in cystic fibrosis. International Journal of Biochemistry & Cell Biology, 2014, 52:73-6
• Carbone A., Castellani S., Favia M. et al., Correction of defective CFTR/ENaC function and tightness of cystic fibrosis airway epithelium by amniotic mesenchymal stromal (stem) cells. J. Cell. Mol. Med., 2014, 18(8):1631-43
• Pesce E., Bellotti M., Liessi N. et al., Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis. European Journal of Medicinal Chemistry, 2015, 99:14-35
• Caci E., Scudieri P., Di Carlo E. et al., Upregulation of TMEM16A Protein in Bronchial Epithelial Cells by Bacterial Pyocyanin. PLoS ONE, 2015, 10(6):e0131775
• Liessi N, Cichero E, Pesce E et al. Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools. Eur J Med Chem. 2018 Jan 20;144:179-200. doi: 10.1016/j.ejmech.2017.12.030. Epub 2017 Dec 8.
• Nara Liessi, Elena Cichero, Emanuela Pesce, Nicoletta Pedemonte, Annalisa Salis, Bruno Tasso, Gianluca Damonte, Giada Righetti, Paola Fossa and Enrico Millo. Pharmacophore and pharmacokinetic filtering tools guiding for the design and synthesis of novel thiazole-containing and VX-809 hybrid derivatives as F508del correctors. The Proceedings of the 16th Italian Convention of Investigators in Cystic Fibrosis. Multidisciplinary Respiratory Medicine, 2019, 14 (Suppl 1):5