Valeria Casavola

Valeria Casavola è Professore Ordinario in Fisiologia Generale presso l’Università degli Studi di Bari. Si è laureata presso lo stesso ateneo in Scienze Biologiche nel 1973. L’attuale campo di interesse è quello di chiarire l’organizzazione e le dinamiche delle interazioni proteina-proteina alla base della regolazione di trasportatori ionici cellulari che risultano alterati in differenti stati patologici. In particolare, la ricerca attuale è condotta in cellule umane delle vie aeree e riguarda: 1) i meccanismi e le dinamiche delle interazioni mediante le quali la proteina a domini PDZ, NHERF, regola l’inserzione del canale CFTR sulla membrana apicale e la sua attività una volta inserita in situ, 2) la compartimentalizzazione spazio-temporale della PKA in cellule bronchiolari polarizzate provenienti da soggetti sani e da soggetti affetti da fibrosi cistica.

• Zaccolo M, Use of Chimeric Fluorescent Proteins and Fluorescence Resonance Energy Transfer to Monitor Cellular Responses, Circulation Research, 2004, 94(7):866-73
• Mongillo M, McSorley T, Evellin S et al., Fluorescence Resonance Energy Transfer-Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases, Circulation Research, 2004, 95(1):67-75
• Abrahamsen H1, Baillie G, Ngai J et al., TCR – and CD28 Mediated Recruitment of Phosphodiesterase 4 to Lipid Rafts Potentiates T Cell Receptor Signaling, Journal of Immunology, 2004, 173(8):4847-58
• Guerra L, Favia M, Fanelli T et al., Stimulation of Xenopus P2Y1 receptor activates CFTR in A6 cells, Pflugers Arch, 2004, 449(1):66-75
• Cardone RA, Bagorda A, Bellizzi A et al., Protein kinase A gating of a pseudopodial-located rhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines, Mol Biol Cell, 2005,16(7):3117-27
• Pantano S, Zacolo M, Carloni P et al., Molecular basis of the allosteric mechanism of cAMP in the regulatory PKA subunit, FEBS Letters, 2005, 579(12):2679-85
• Guerra L, Fanelli T, Favia M et al., Na+/H+ exchanger regulatory factor isoform 1 overexpression modulates cystic fibrosis transmembrane conductance regulator (CFTR) expression and activity in human airway 16HBE14o- cells and rescues DeltaF508 CFTR functional expression in cystic fibrosis cells, J Biol Chem, 2005, 280(49):40925-33
• Favia M, Fanelli T, Bagorda A et al., NHE3 inhibits PKA-dependent functional expression of CFTR by NHERF2 PDZ interactions, Biochem Biophys Res Commun., 2006, 25;347(2):452-9
• Favia M, Guerra L, Fanelli T et al., Na+/H+ exchanger regulatory factor 1 overexpression-dependent increase of cytoskeleton organization is fundamental in the rescue of F508del cystic fibrosis transmembrane conductance regulator in human airway CFBE41o- Cells, Mol Biol Cell., 2010, 21(1):73-86
• Monterisi S, Favia M, Guerra L et al., CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartimetalized cAMP and PKA activity, J Cell Sci, 2012, Mar 1;125(Pt 5):1106-17
• Castellani S, Guerra L, Favia M et al., NHERF1 and CFTR restore tight junction organisation and function in cystic fibrosis airway epithelial cells: role of ezrin and the RhoA/ROCK pathway, Laboratory Investigation, 2012, 92(11):1527-40
• Favia M, Mancini MT1, Bezzerri V et al., Trimethylangelicin promotes the functional rescue of mutant F508del CFTR protein in cystic fibrosis airway cells, Am J Physiol Lung Cell Mol Physiol, 2014, 307(1):L48-61
• Abbattiscianni AC, Favia M, Mancini MT et al., Correctors of mutant CFTR enhance subcortical cAMP/PKA signaling via ezrin phosphorylation and cytoskeleton organization, J Cell Sci, 2016, 129(6):1128-40
• Trotta T, Guerra L, Piro D et al., Stimulation of β2-adrenergic receptor increases CFTR function and decreases ATP levels in murine hematopoietic stem/progenitor cells, J Cyst Fibros, 2015, 14(1):26-33
• Fanelli T, Cardone RA, Favia M et al., Beta-oestradiol rescues DeltaF508CFTR functional expression in human cystic fibrosis airway CFBE41o- cells through the up-regulation of NHERF1, Biol Cell. 2008, 100(7):399- 412 
• Laselva O, Molinski S, Casavola V, Bear CE, The investigational Cystic Fibrosis drug Trimethylangelicin directly modulates CFTR by stabilizing the first membrane-spanning domain, 2016