Alessandra Bragonzi

Alessandra Bragonzi è Ricercatore, responsabile di gruppo di ricerca, presso l’Unità di Infezioni e Fibrosi Cistica dell’Istituto Scientifico San Raffaele di Milano. Ha maturato esperienza come borsista Telethon presso Institute for Gene Therapy (TIGET) dell’Istituto San Raffaele. Ha svolto la sua attività di dottorato e post-dottorato presso Università Eberhard Karls, Tübingen, Germania, dove ha maturato esperienza su Infezioni in Fibrosi Cistica.
Dal 2009 è la responsabile del servizio CFaCore (Cystic Fibrosis animal Core Facility), al suo secondo triennio di attività, che offre un insieme di competenze, servizi e infrastrutture che consentono ai ricercatori impegnati in progetti di ricerca finanziati da FFC di utilizzare modelli murini pre-clinici di FC per studi di tipo patogenetico e terapeutico. L’obiettivo è quello di trasferire le conoscenze di base ad applicazioni pre-cliniche favorendo lo sviluppo di nuove strategie per il trattamento della FC.

• Chiarini L, Bevivino A, Dalmastri C et al., Burkholderia Cepacia complex species: health hazards and biotechnological potential. Trends in Microbiology, 2006, 14(6):277-86
• Pirone L. Bragonzi A, Farcomeni A et al., Burkholderia cenocepacia strains isolated from cystic fibrosis patients are apparently more invasive and more virulent than rhizosphere strains. Enviromental Microbiology, 2008, 10(10):2773-84
• Bianconi I, Milani A, Cigana C et al., Positive signature-tagged mutagenesis in Pseudomonas aeruginosa: tracking patho-adaptive mutations promoting airways chronic infection. PLOS Pathogens, 2011, 7(2):e1001270
• Alcalá-Franco B, Montanari S, Cigana C et al., Antibiotic pressure compensates the biological cost associated with Pseudomonas aeruginosa hypermutable phenotypes in vitro and in a murine model of chronic airways infection. Journal of Antimicrobial Chemotherapy, 2012, 67(4):962-9
• Vecchietti D, Di Silvestre D, Miriani M et al., Analysis of Pseudomonas aeruginosa cell envelope proteome by capture of surface-exposed proteins on activated magnetic nanoparticles. PLoS ONE 2012, 7(11):e51062
• Baldan R, Testa F, Lorè NI et al., Factors contributing to epidemic MRSA clones replacement in a hospital setting. PLoS ONE, 2012, 7(8):e43153
• Bragonzi A, Farulla I, Paroni M et al., Modelling co-infection of the cystic fibrosis lung by Pseudomonas aeruginosa and Burkholderia cenocepacia reveals influence on biofilm formation and host response. PLoS ONE, 2012, 7(12):e52330
• Bragonzi A, Worlitzsch D, Pier GB et al., Nonmucoid Pseudomonas aeruginosa expresses alginate in the lungs of patients with cystic fibrosis and in a mouse model. J Infect Dis., 2005, 192(3):410-9
• Bragonzi A, Wiehlmann L, Klockgether J et al., Sequence diversity of the mucABD locus in Pseudomonas aeruginosa isolates from patients with cystic fibrosis. Microbiology, 2006, 152(Pt 11):3261-9
• Bragonzi A, Paroni M, Nonis A et al., Pseudomonas aeruginosa microevolution during cystic fibrosis lung infection establishes clones with adapted virulence. Am J Respir Crit Care Med, 2009, 180(2):138-45
• Bottazzi B, Garlanda C, Cotena A et al., The long pentraxin PTX3 as a prototypic humoral pattern recognition receptor: interplay with cellular innate immunity. Immunol Rev, 2009, 227(1):9-18
• Chiarini M, Sabelli C, Melotti P et al., PTX3 genetic variations affect the risk of Pseudomonas aeruginosa airway colonization in cystic fibrosis patients. Genes Immun, 2010, 11(8): 665–670
• Bottazzi B, Doni A, Garlanda C, Mantovani A., An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm. Annu Rev Immunol., 2010, 28:157-83
• Moalli F, Doni A, Deban L et al. Role of Complement and Fcγ receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus. Blood, 2010, 116:5170-5180
• Galletti P, Cocuzza CE, Pori M et al. Antibacterial agents and cystic fibrosis: synthesis and antimicrobial evaluation of a series of N-thiomethylazetidinones. ChemMedChem, 2011, 6(10):1919-27
• Moalli F, Paroni M, Véliz Rodriguez T et al., The Therapeutic Potential of the Humoral Pattern Recognition Molecule PTX3 in chronic lung infection caused by Pseudomonas aeruginosa. J Immunol, 2011, 186(9):5425-34
• Inforzato A, Jaillon S, Moalli F et al., The long pentraxin PTX3 at the crossroads between innate immunity and tissue remodelling. Tissue Antigens, 2011, 77(4):271-82
• Doni A, Garlanda C, Bottazzi B et al., Interactions of the humoral pattern recognition molecule PTX3 with the complement system. Immunobiology, 2012, 217(11):1122-8
• Paroni M, Moalli F, Nebuloni M et al., Response of CFTR-Deficient Mice to Long-Term chronic Pseudomonas aeruginosa Infection and PTX3 Therapy. J Infect Dis., 2013, 208(1):130-8
• Véliz Rodriguez T, Moalli F, Polentarutti N et al., Role of toll interleukin-1 receptor (IL-1R), a negative regulator of IL-1R/toll like receptor signaling, in resistance to acute Pseudomonas lung infection. Infect Immun, 2012, ;80(1):100-9
• Garlanda C, Riva F, Bonavita E, Gentile S, Mantovani A., Decoys and Regulatory “Receptors” of the IL-1/Toll-Like Receptor Superfamily. Frontiers in Immunology, 2013, 9;4:180
• Garlanda C, Riva F, Bonavita E, Mantovani A., Negative regulatory receptors of the IL-1 family. Seminars in Immunology, 2013, 25(6):408-15
• P Montuschi, D Paris, S Montella et al., Letter to Editor- Nuclear Magnetic Resonance–based Metabolomics Discriminates Primary Ciliary Dyskinesia from Cystic Fibrosis. American Journal of Respiratory and Critical Care Medicine, 2014, 190(2)
• Baldan R, Cigana C, Testa F, et al., Adaptation of Pseudomonas aeruginosa in Cystic Fibrosis airways influences virulence of Staphylococcus aureus in vitro and murine models of co-infection. PLoS ONE, 2014
• Lorè NI, Iraqi FA, Bragonzi A., Host genetic diversity influences the severity of Pseudomonas aeruginosa pneumonia in the Collaborative Cross mice. BMC Genet, 2015, 16:106 
• Inforzato A, Bottazzi B, Garlanda C et al., Pentraxins in humoral innate immunity. Adv. in Experimental Medicine and Biology, 2012, 946:1-20
• Bragonzi A, Horati H, Kerrigan L, et al., Inflammation and host-pathogen interaction: Cause and consequence in cystic fibrosis lung disease. J Cyst Fibros. 2018 Mar;17(2S):S40-S45. doi: 10.1016/j.jcf.2017.10.004. Epub 2017 Oct 27.
• Nicola Ivan Loré, Claudia Caslini, Gengming He, Lisa Strug, Migliara Alessandro, Angelo Lombardo, Lisa Provezza, Giulio Cabrini, Rizzo Giulia, Barbara Sipione, Emanuela Caci, Louis Galietta, Harriet Corvol, Alessandra Bragonzi. Cystic fibrosis modifier genes related to Pseudomonas aeruginosa lung disease. The Proceedings of the 16th Italian Convention of Investigators in Cystic Fibrosis. Multidisciplinary Respiratory Medicine, 2019, 14 (Suppl 1):5